“All the pieces matter”

The RNA Silencing Pathway: The Bits and Pieces That Matter

Cellular pathways are generally proposed on the basis of available experimental knowledge. The proposed pathways, however, may be inadequate to describe the phenomena they are supposed to explain. For instance, by means of concise mathematical models we are able to reveal shortcomings in the current description of the pathway of RNA silencing. The silencing pathway operates by cleaving siRNAs f...

Tissue-tracking requirements: putting all the pieces together.

Dark Chocolate and Metabolic Syndrome; Do Polyphenols All that Matter?

Cellular mechanotransduction: putting all the pieces together again.

Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other ...

Dark matter cores all the way down

We use high-resolution simulations of isolated dwarf galaxies to study the physics of dark matter cusp-core transformations at the edge of galaxy formation: M200 = 107–109 M . We work at a resolution (∼4 pcminimumcell size;∼250M per particle) atwhich the impact from individual supernovae explosions can be resolved, becoming insensitive to even large changes in our numerical ‘sub-grid’ parameter...